Assay Detail
Binding
CHEMBL3377151
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Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alpha-ethyltryptamines as dual dopamine-serotonin releasers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.17 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471839 | — | — | 1 | 7.96 |
| CHEMBL96816 | — | — | 1 | 7.11 |
| CHEMBL30713 | — | — | 1 | 6.95 |
| CHEMBL337825 | — | — | 1 | 6.33 |
| CHEMBL275628 | — | — | 1 | 6.33 |
| CHEMBL3330646 | — | — | 1 | 6.23 |
| CHEMBL1619758 | ETRYPTAMINE | 2.0 | 1 | 6.19 |
| CHEMBL3330643 | — | — | 1 | 6.18 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.14 |
| CHEMBL348588 | — | — | 1 | 6.13 |
| CHEMBL382635 | — | — | 1 | 5.95 |
| CHEMBL381160 | — | — | 1 | 5.80 |
| CHEMBL1906905 | — | — | 1 | 5.46 |
| CHEMBL3330645 | — | — | 1 | 5.43 |
| CHEMBL3330648 | — | — | 1 | 5.27 |
| CHEMBL3330644 | — | — | 1 | 5.25 |
| CHEMBL1288717 | — | — | 1 | - |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | - |
| CHEMBL1288716 | — | — | 1 | - |
| CHEMBL3330642 | — | — | 1 | - |
| CHEMBL204839 | — | — | 1 | - |
| CHEMBL331241 | — | — | 1 | - |
| CHEMBL343529 | — | — | 1 | - |
| CHEMBL3330641 | — | — | 1 | - |
| CHEMBL3330647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471839 | — | EC50 | = | 11.1 | nM | 7.96 |
| CHEMBL96816 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL30713 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL337825 | — | EC50 | = | 465.0 | nM | 6.33 |
| CHEMBL275628 | — | EC50 | = | 464.0 | nM | 6.33 |
| CHEMBL3330646 | — | EC50 | = | 592.0 | nM | 6.23 |
| CHEMBL1619758 | ETRYPTAMINE | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3330643 | — | EC50 | = | 656.0 | nM | 6.18 |
| CHEMBL6640 | TRYPTAMINE | EC50 | = | 716.0 | nM | 6.14 |
| CHEMBL348588 | — | EC50 | = | 733.0 | nM | 6.13 |
| CHEMBL382635 | — | EC50 | = | 1123.0 | nM | 5.95 |
| CHEMBL381160 | — | EC50 | = | 1575.0 | nM | 5.80 |
| CHEMBL1906905 | — | EC50 | = | 3434.0 | nM | 5.46 |
| CHEMBL3330645 | — | EC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3330648 | — | EC50 | = | 5334.0 | nM | 5.27 |
| CHEMBL3330644 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1288717 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | EC50 | > | 10000.0 | nM | - |
| CHEMBL1288716 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3330642 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL204839 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL331241 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL343529 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3330641 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3330647 | — | EC50 | > | 10000.0 | nM | - |