Assay Detail
Functional
CHEMBL3380159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sphingosine 1-phosphate receptor 1 (CHEMBL1914263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 10.22 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359523 | — | — | 1 | 10.30 |
| CHEMBL3359522 | — | — | 1 | 10.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359523 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL3359522 | — | EC50 | = | 0.072 | nM | 10.14 |