Assay Detail
Binding
CHEMBL3380177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IRAK4 (unknown origin)
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.26 | 9.62 |
| Ki | 1 | 8.92 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353189 | — | — | 1 | 9.62 |
| CHEMBL3353188 | — | — | 1 | 9.44 |
| CHEMBL3353219 | — | — | 1 | 9.00 |
| CHEMBL1236126 | — | — | 1 | 8.92 |
| CHEMBL3353205 | — | — | 1 | 8.70 |
| CHEMBL3353202 | — | — | 1 | 8.22 |
| CHEMBL3353220 | — | — | 1 | 8.10 |
| CHEMBL3353203 | — | — | 1 | 7.85 |
| CHEMBL3353204 | — | — | 1 | 7.80 |
| CHEMBL3353187 | — | — | 1 | 7.68 |
| CHEMBL3353206 | — | — | 1 | 7.50 |
| CHEMBL3353210 | — | — | 1 | 7.00 |
| CHEMBL3353207 | — | — | 1 | - |
| CHEMBL3353208 | — | — | 1 | - |
| CHEMBL3353209 | — | — | 1 | - |
| CHEMBL3353217 | — | — | 1 | - |
| CHEMBL3353218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353189 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3353188 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL3353219 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1236126 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3353205 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3353202 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3353220 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3353203 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3353204 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3353187 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3353206 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3353210 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3353207 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3353208 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3353209 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3353217 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3353218 | — | IC50 | <= | 100.0 | nM | - |