Compound Detail
CHEMBL3353203
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Basic Information
| ChEMBL ID | CHEMBL3353203 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BAEMOWYINAFWKT-JSGCOSHPSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
430.5
MW (Da)
2.00
ALogP
8
HBA
3
HBD
95.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 CHEMBL3778 | IC50 | 7.85 | 7.85 | 14.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 14.0 | nM | 7.85 | Inhibition of IRAK4 (unknown origin) | 25479567 |
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 14.0 | nM | 7.85 | IMAP technology (Molecular Devices): A 20 ul reaction mixture contains 10 mM Tri... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25479567 | 10.1021/jm5016044 | Interleukin-1 receptor-associated kinase 4 | 1 |
Data from ChEMBL 36 via Core Engine