Assay Detail
Functional
CHEMBL3380437
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Cytotoxicity against human THP1 cells assessed as cell viability after 48 hrs by MTT assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 6.99 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | 7.60 |
| CHEMBL3329685 | — | — | 1 | 7.49 |
| CHEMBL3329683 | — | — | 1 | 7.38 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.34 |
| CHEMBL3329684 | — | — | 1 | 7.31 |
| CHEMBL3329669 | — | — | 1 | 7.28 |
| CHEMBL3329677 | — | — | 1 | 7.27 |
| CHEMBL3329675 | — | — | 1 | 7.25 |
| CHEMBL3329673 | — | — | 1 | 7.21 |
| CHEMBL3329682 | — | — | 1 | 7.20 |
| CHEMBL3329679 | — | — | 1 | 7.19 |
| CHEMBL3329671 | — | — | 1 | 7.19 |
| CHEMBL3329652 | — | — | 1 | 7.17 |
| CHEMBL3329668 | — | — | 1 | 7.16 |
| CHEMBL3329660 | — | — | 1 | 7.16 |
| CHEMBL3329681 | — | — | 1 | 7.15 |
| CHEMBL3329676 | — | — | 1 | 7.13 |
| CHEMBL3329674 | — | — | 1 | 7.12 |
| CHEMBL3329664 | — | — | 1 | 7.11 |
| CHEMBL3329672 | — | — | 1 | 7.10 |
| CHEMBL3329656 | — | — | 1 | 7.09 |
| CHEMBL3329670 | — | — | 1 | 7.09 |
| CHEMBL3330971 | — | — | 1 | 7.05 |
| CHEMBL3329657 | — | — | 1 | 7.04 |
| CHEMBL3329678 | — | — | 1 | 7.02 |
| CHEMBL3329680 | — | — | 1 | 6.99 |
| CHEMBL3329665 | — | — | 1 | 6.94 |
| CHEMBL3329663 | — | — | 1 | 6.58 |
| CHEMBL3329655 | — | — | 1 | 6.53 |
| CHEMBL3329662 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL3329685 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL3329683 | — | IC50 | = | 41.2 | nM | 7.38 |
| CHEMBL535 | SUNITINIB | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL3329684 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL3329669 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL3329677 | — | IC50 | = | 53.9 | nM | 7.27 |
| CHEMBL3329675 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL3329673 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL3329682 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL3329679 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3329671 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL3329652 | — | IC50 | = | 68.4 | nM | 7.17 |
| CHEMBL3329668 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3329660 | — | IC50 | = | 68.8 | nM | 7.16 |
| CHEMBL3329681 | — | IC50 | = | 70.3 | nM | 7.15 |
| CHEMBL3329676 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3329674 | — | IC50 | = | 76.3 | nM | 7.12 |
| CHEMBL3329664 | — | IC50 | = | 78.4 | nM | 7.11 |
| CHEMBL3329672 | — | IC50 | = | 79.5 | nM | 7.10 |
| CHEMBL3329656 | — | IC50 | = | 81.2 | nM | 7.09 |
| CHEMBL3329670 | — | IC50 | = | 81.2 | nM | 7.09 |
| CHEMBL3330971 | — | IC50 | = | 88.9 | nM | 7.05 |
| CHEMBL3329657 | — | IC50 | = | 90.9 | nM | 7.04 |
| CHEMBL3329678 | — | IC50 | = | 95.1 | nM | 7.02 |
| CHEMBL3329680 | — | IC50 | = | 102.2 | nM | 6.99 |
| CHEMBL3329665 | — | IC50 | = | 115.8 | nM | 6.94 |
| CHEMBL3329663 | — | IC50 | = | 262.2 | nM | 6.58 |
| CHEMBL3329655 | — | IC50 | = | 293.2 | nM | 6.53 |
| CHEMBL3329662 | — | IC50 | = | 299.9 | nM | 6.52 |
| CHEMBL3329659 | — | IC50 | = | 326.3 | nM | 6.49 |
| CHEMBL3329658 | — | IC50 | = | 331.3 | nM | 6.48 |
| CHEMBL3329661 | — | IC50 | = | 355.7 | nM | 6.45 |
| CHEMBL3329650 | — | IC50 | = | 355.8 | nM | 6.45 |
| CHEMBL3329651 | — | IC50 | = | 373.2 | nM | 6.43 |
| CHEMBL3361346 | — | IC50 | = | 375.2 | nM | 6.43 |
| CHEMBL3330970 | — | IC50 | = | 381.5 | nM | 6.42 |
| CHEMBL3329653 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329686 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329687 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330968 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330969 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329667 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330972 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329666 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3361347 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330975 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330976 | — | IC50 | > | 500.0 | nM | - |