Assay Detail
ADMET
CHEMBL3380639
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Inhibition of CYP2C9 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.53 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359017 | — | — | 1 | 6.48 |
| CHEMBL3359014 | — | — | 1 | 6.47 |
| CHEMBL3359019 | — | — | 1 | 6.24 |
| CHEMBL3359023 | — | — | 1 | 6.00 |
| CHEMBL3359022 | — | — | 1 | 5.25 |
| CHEMBL3359020 | — | — | 1 | 5.06 |
| CHEMBL3359018 | — | — | 1 | 4.89 |
| CHEMBL3359024 | — | — | 1 | 4.77 |
| CHEMBL3359021 | — | — | 1 | 4.57 |
| CHEMBL1230001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359017 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3359014 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3359019 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3359023 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3359022 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3359020 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3359018 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3359024 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3359021 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1230001 | — | IC50 | > | 100000.0 | nM | - |