Assay Detail
Binding
CHEMBL3380976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HIV-1 TAR RNA by Tat-TAR fluorimetric competition assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 3.75 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6885 | QUINAZOLINE-2,4,6-TRIAMINE | — | 1 | 4.40 |
| CHEMBL3357801 | — | — | 1 | 4.35 |
| CHEMBL3357793 | — | — | 1 | 4.30 |
| CHEMBL3357802 | — | — | 1 | 4.30 |
| CHEMBL3357800 | — | — | 1 | 4.30 |
| CHEMBL337414 | — | — | 1 | 4.30 |
| CHEMBL3357347 | — | — | 1 | 4.30 |
| CHEMBL3357805 | — | — | 1 | 4.22 |
| CHEMBL3357804 | — | — | 1 | 4.16 |
| CHEMBL3357799 | — | — | 1 | 3.96 |
| CHEMBL3357803 | — | — | 1 | 3.89 |
| CHEMBL3357797 | — | — | 1 | 3.82 |
| CHEMBL3357794 | — | — | 1 | 3.82 |
| CHEMBL268354 | — | — | 1 | 3.40 |
| CHEMBL3357798 | — | — | 1 | 3.15 |
| CHEMBL3357796 | — | — | 1 | 3.12 |
| CHEMBL3357795 | — | — | 1 | 2.70 |
| CHEMBL268456 | — | — | 1 | 2.70 |
| CHEMBL62083 | — | — | 1 | 2.10 |
| CHEMBL6993 | — | — | 1 | - |
| CHEMBL3357346 | — | — | 1 | - |
| CHEMBL305513 | — | — | 1 | - |
| CHEMBL2392115 | — | — | 1 | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | - |
| CHEMBL88580 | — | — | 1 | - |
| CHEMBL3357345 | — | — | 1 | - |
| CHEMBL3357344 | — | — | 1 | - |
| CHEMBL3357343 | — | — | 1 | - |
| CHEMBL1200728 | GUANIDINE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6885 | QUINAZOLINE-2,4,6-TRIAMINE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3357801 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3357793 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3357802 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3357800 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL337414 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3357347 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3357805 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3357804 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL3357799 | — | IC50 | = | 110000.0 | nM | 3.96 |
| CHEMBL3357803 | — | IC50 | = | 130000.0 | nM | 3.89 |
| CHEMBL3357797 | — | IC50 | = | 150000.0 | nM | 3.82 |
| CHEMBL3357794 | — | IC50 | = | 150000.0 | nM | 3.82 |
| CHEMBL268354 | — | IC50 | = | 400000.0 | nM | 3.40 |
| CHEMBL3357798 | — | IC50 | = | 700000.0 | nM | 3.15 |
| CHEMBL3357796 | — | IC50 | = | 750000.0 | nM | 3.12 |
| CHEMBL3357795 | — | IC50 | = | 2000000.0 | nM | 2.70 |
| CHEMBL268456 | — | IC50 | = | 2000000.0 | nM | 2.70 |
| CHEMBL62083 | — | IC50 | = | 8000000.0 | nM | 2.10 |
| CHEMBL6993 | — | IC50 | > | 20000000.0 | nM | - |
| CHEMBL3357346 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL305513 | — | IC50 | > | 11000000.0 | nM | - |
| CHEMBL2392115 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | IC50 | > | 20000000.0 | nM | - |
| CHEMBL88580 | — | IC50 | > | 20000000.0 | nM | - |
| CHEMBL3357345 | — | IC50 | > | 20000000.0 | nM | - |
| CHEMBL3357344 | — | IC50 | > | 20000000.0 | nM | - |
| CHEMBL3357343 | — | IC50 | > | 20000000.0 | nM | - |
| CHEMBL1200728 | GUANIDINE HYDROCHLORIDE | IC50 | > | 20000000.0 | nM | - |