Assay Detail
Functional
CHEMBL3381044
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Antiproliferative activity against human A2780 cells after 72 hrs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 9.00 |
| CHEMBL3310151 | — | — | 1 | 5.81 |
| CHEMBL3309998 | — | — | 1 | 5.67 |
| CHEMBL3309997 | — | — | 1 | 5.67 |
| CHEMBL3310003 | — | — | 1 | 5.44 |
| CHEMBL3309988 | — | — | 1 | 5.30 |
| CHEMBL3309995 | — | — | 1 | 5.22 |
| CHEMBL3310152 | — | — | 1 | 5.19 |
| CHEMBL3309990 | — | — | 1 | 5.18 |
| CHEMBL3310155 | — | — | 1 | 5.16 |
| CHEMBL3309999 | — | — | 1 | 5.09 |
| CHEMBL3309269 | — | — | 1 | 5.09 |
| CHEMBL3310001 | — | — | 1 | 5.08 |
| CHEMBL3309989 | — | — | 1 | 5.05 |
| CHEMBL3309991 | — | — | 1 | 5.04 |
| CHEMBL3310000 | — | — | 1 | 5.04 |
| CHEMBL3310002 | — | — | 1 | 5.04 |
| CHEMBL3310156 | — | — | 1 | 5.04 |
| CHEMBL3310004 | — | — | 1 | 5.02 |
| CHEMBL3309985 | — | — | 1 | 5.00 |
| CHEMBL3309993 | — | — | 1 | 4.96 |
| CHEMBL3309994 | — | — | 1 | 4.96 |
| CHEMBL3309996 | — | — | 1 | - |
| CHEMBL3310153 | — | — | 1 | - |
| CHEMBL3310154 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3310151 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3309998 | — | IC50 | = | 2116.0 | nM | 5.67 |
| CHEMBL3309997 | — | IC50 | = | 2119.0 | nM | 5.67 |
| CHEMBL3310003 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3309988 | — | IC50 | = | 5047.0 | nM | 5.30 |
| CHEMBL3309995 | — | IC50 | = | 5961.0 | nM | 5.22 |
| CHEMBL3310152 | — | IC50 | = | 6516.0 | nM | 5.19 |
| CHEMBL3309990 | — | IC50 | = | 6613.0 | nM | 5.18 |
| CHEMBL3310155 | — | IC50 | = | 6948.0 | nM | 5.16 |
| CHEMBL3309999 | — | IC50 | = | 8112.0 | nM | 5.09 |
| CHEMBL3309269 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL3310001 | — | IC50 | = | 8303.0 | nM | 5.08 |
| CHEMBL3309989 | — | IC50 | = | 8823.0 | nM | 5.05 |
| CHEMBL3309991 | — | IC50 | = | 9030.0 | nM | 5.04 |
| CHEMBL3310000 | — | IC50 | = | 9189.0 | nM | 5.04 |
| CHEMBL3310002 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL3310156 | — | IC50 | = | 9103.0 | nM | 5.04 |
| CHEMBL3310004 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3309985 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3309993 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3309994 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL3309996 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3310153 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3310154 | — | IC50 | > | 10000.0 | nM | - |