Assay Detail
Functional
CHEMBL3381607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human TZM-bl cells assessed as viral inhibition pre-incubated for 30 mins prior to infection measured after 48 hrs by
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 76 | 7.57 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.00 |
| CHEMBL3338020 | — | — | 1 | 9.00 |
| CHEMBL3338005 | — | — | 1 | 9.00 |
| CHEMBL3338055 | — | — | 1 | 9.00 |
| CHEMBL302791 | — | — | 1 | 8.70 |
| CHEMBL3338050 | — | — | 1 | 8.70 |
| CHEMBL3338049 | — | — | 1 | 8.70 |
| CHEMBL69503 | — | — | 1 | 8.70 |
| CHEMBL71728 | — | — | 1 | 8.70 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 8.70 |
| CHEMBL3338027 | — | — | 1 | 8.70 |
| CHEMBL470025 | — | — | 1 | 8.70 |
| CHEMBL3338019 | — | — | 1 | 8.70 |
| CHEMBL71521 | — | — | 1 | 8.70 |
| CHEMBL3338008 | — | — | 1 | 8.70 |
| CHEMBL3338052 | — | — | 1 | 8.52 |
| CHEMBL3338018 | — | — | 1 | 8.52 |
| CHEMBL54893 | UC 781 | 1.0 | 1 | 8.52 |
| CHEMBL71659 | — | — | 1 | 8.52 |
| CHEMBL3338023 | — | — | 1 | 8.52 |
| CHEMBL72529 | — | — | 1 | 8.52 |
| CHEMBL571987 | LERSIVIRINE | 2.0 | 1 | 8.52 |
| CHEMBL3338010 | — | — | 1 | 8.40 |
| CHEMBL3338021 | — | — | 1 | 8.40 |
| CHEMBL74174 | — | — | 1 | 8.40 |
| CHEMBL3338028 | — | — | 1 | 8.30 |
| CHEMBL3338026 | — | — | 1 | 8.15 |
| CHEMBL3338016 | — | — | 1 | 8.10 |
| CHEMBL421114 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3338055 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3338005 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3338020 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3338049 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL302791 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3338050 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL69503 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL71728 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3338008 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3338027 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL470025 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3338019 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL71521 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL571987 | LERSIVIRINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL72529 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3338023 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL71659 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3338052 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL54893 | UC 781 | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3338018 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL74174 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3338010 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3338021 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3338028 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3338026 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3338016 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL421114 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3338012 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3338013 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3338022 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3338017 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3338009 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3338030 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3338031 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3338034 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3338051 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3338025 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3338029 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL593 | DELAVIRDINE | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3338037 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3338015 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3338054 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3338033 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3338024 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3338032 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3338053 | — | EC50 | = | 158.0 | nM | 6.80 |