Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3338033

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1cc(Br)c(Nc2nc(Nc3ccc(C#N)cc3)nc(N3CCCCC3)n2)c(Br)c1

Basic Information

ChEMBL ID CHEMBL3338033
Phase Preclinical
Structure Type MOL
InChI Key AMQWQTRQRHNWRG-UHFFFAOYSA-N
6
Targets
6
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

543.3
MW (Da)
6.05
ALogP
7
HBA
2
HBD
89.8
PSA (Ų)
0.40
QED
2
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H21Br2N7
MW 543.27
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.53

Activity Summary

IC50 5 meas. best 5.91
EC50 1 meas. best 6.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
EC50 6.92 6.92 120.0 1
Trypanosoma brucei rhodesiense
CHEMBL612348
IC50 5.91 5.91 1220.0 1
Trypanosoma brucei brucei
CHEMBL612851
IC50 5.78 5.78 1680.0 1
Trypanosoma cruzi
CHEMBL368
IC50 5.4 5.4 4020.0 1
Leishmania infantum
CHEMBL612848
IC50 5.28 5.28 5220.0 1
Plasmodium falciparum
CHEMBL364
IC50 5.18 5.18 6620.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25199582 10.1016/j.bmc.2014.08.005 ADMET 2
25199582 10.1016/j.bmc.2014.08.005 Trypanosoma brucei brucei 1
25199582 10.1016/j.bmc.2014.08.005 Trypanosoma brucei rhodesiense 1
25199582 10.1016/j.bmc.2014.08.005 Human immunodeficiency virus 1 1
25199582 10.1016/j.bmc.2014.08.005 Trypanosoma cruzi 1
25199582 10.1016/j.bmc.2014.08.005 Leishmania infantum 1
25199582 10.1016/j.bmc.2014.08.005 Plasmodium falciparum 1

Data from ChEMBL 36 via Core Engine