Assay Detail
Functional
CHEMBL3382913
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Trypanocidal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as parasite growth inhibition after 168 hrs by beta-galactosidase assay
78
Total Activities
78
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.25 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3338018 | — | — | 1 | 6.20 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.16 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 5.90 |
| CHEMBL3338027 | — | — | 1 | 5.78 |
| CHEMBL3338030 | — | — | 1 | 5.77 |
| CHEMBL3338032 | — | — | 1 | 5.70 |
| CHEMBL3338035 | — | — | 1 | 5.69 |
| CHEMBL3338029 | — | — | 1 | 5.67 |
| CHEMBL3338034 | — | — | 1 | 5.62 |
| CHEMBL69503 | — | — | 1 | 5.60 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.59 |
| CHEMBL3338009 | — | — | 1 | 5.49 |
| CHEMBL3338048 | — | — | 1 | 5.41 |
| CHEMBL3338025 | — | — | 1 | 5.41 |
| CHEMBL3338033 | — | — | 1 | 5.40 |
| CHEMBL3337998 | — | — | 1 | 5.39 |
| CHEMBL578061 | — | — | 1 | 5.35 |
| CHEMBL3338054 | — | — | 1 | 5.35 |
| CHEMBL3338023 | — | — | 1 | 5.31 |
| CHEMBL3338020 | — | — | 1 | 5.31 |
| CHEMBL3338045 | — | — | 1 | 5.28 |
| CHEMBL3338013 | — | — | 1 | 5.28 |
| CHEMBL3338028 | — | — | 1 | 5.25 |
| CHEMBL470025 | — | — | 1 | 5.18 |
| CHEMBL302791 | — | — | 1 | 5.17 |
| CHEMBL3338041 | — | — | 1 | 5.17 |
| CHEMBL71659 | — | — | 1 | 5.15 |
| CHEMBL3338038 | — | — | 1 | 5.13 |
| CHEMBL3338026 | — | — | 1 | 5.13 |
| CHEMBL71521 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3338018 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL70663 | DAPIVIRINE | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3338027 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3338030 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL3338032 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL3338035 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL3338029 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL3338034 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL69503 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3338009 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL3338025 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL3338048 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL3338033 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL3337998 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL578061 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL3338054 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL3338023 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL3338020 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL3338045 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL3338013 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL3338028 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL470025 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL3338041 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL302791 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL71659 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL3338038 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL3338026 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL71521 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL3338047 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3338040 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL3338022 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL421114 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL3338024 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL3338044 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL74174 | — | IC50 | = | 11510.0 | nM | 4.94 |
| CHEMBL3338031 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL3338052 | — | IC50 | = | 14980.0 | nM | 4.82 |
| CHEMBL3338043 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3338049 | — | IC50 | = | 27880.0 | nM | 4.55 |
| CHEMBL3338036 | — | IC50 | = | 30110.0 | nM | 4.52 |
| CHEMBL3338006 | — | IC50 | = | 46910.0 | nM | 4.33 |
| CHEMBL3338012 | — | IC50 | = | 47740.0 | nM | 4.32 |
| CHEMBL3338050 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3338051 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3338053 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3337999 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 64000.0 | nM | - |