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Compound Detail

CHEMBL3338048

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Cc1cc(C)c(Oc2nc(Cl)nc(Nc3cccc(C#N)c3)n2)c(C)c1

Basic Information

ChEMBL ID CHEMBL3338048
Phase Preclinical
Structure Type MOL
InChI Key JSCCKPRMWSEEFJ-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

365.8
MW (Da)
4.86
ALogP
6
HBA
1
HBD
83.7
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H16ClN5O
MW 365.82
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.53

Activity Summary

IC50 6 meas. best 5.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Leishmania infantum
CHEMBL612848
IC50 5.82 5.82 1500.0 1
Trypanosoma cruzi
CHEMBL368
IC50 5.41 5.41 3920.0 1
Plasmodium falciparum
CHEMBL364
IC50 5.35 5.35 4500.0 1
Trypanosoma brucei brucei
CHEMBL612851
IC50 5.28 5.28 5200.0 1
ADMET
CHEMBL612558
IC50 5.1 5.1 8010.0 1
Trypanosoma brucei rhodesiense
CHEMBL612348
IC50 4.67 4.67 21400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25199582 10.1016/j.bmc.2014.08.005 ADMET 2
25199582 10.1016/j.bmc.2014.08.005 Trypanosoma brucei brucei 1
25199582 10.1016/j.bmc.2014.08.005 Trypanosoma brucei rhodesiense 1
25199582 10.1016/j.bmc.2014.08.005 Human immunodeficiency virus 1 1
25199582 10.1016/j.bmc.2014.08.005 Trypanosoma cruzi 1
25199582 10.1016/j.bmc.2014.08.005 Leishmania infantum 1
25199582 10.1016/j.bmc.2014.08.005 Plasmodium falciparum 1

Data from ChEMBL 36 via Core Engine