Assay Detail
Binding
CHEMBL3383292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK-1 (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.45 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406821 | — | — | 1 | 8.30 |
| CHEMBL3338837 | — | — | 1 | 7.92 |
| CHEMBL1956071 | — | — | 1 | 7.85 |
| CHEMBL2147538 | — | — | 1 | 7.68 |
| CHEMBL1214929 | — | — | 1 | 7.52 |
| CHEMBL3338838 | — | — | 1 | 7.50 |
| CHEMBL3338839 | — | — | 1 | 7.44 |
| CHEMBL3338840 | — | — | 1 | 7.41 |
| CHEMBL3338842 | — | — | 1 | 7.28 |
| CHEMBL559147 | Y-27632 | — | 1 | 7.03 |
| CHEMBL3338841 | — | — | 1 | 6.85 |
| CHEMBL3338843 | — | — | 1 | 6.63 |
| CHEMBL3338844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406821 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3338837 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1956071 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2147538 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1214929 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3338838 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3338839 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3338840 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3338842 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL559147 | Y-27632 | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3338841 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3338843 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3338844 | — | IC50 | > | 1000.0 | nM | - |