Assay Detail
Binding
CHEMBL3384492
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Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate
34
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.83 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356971 | — | — | 2 | 8.57 |
| CHEMBL3356980 | — | — | 2 | 8.47 |
| CHEMBL3356960 | — | — | 2 | 8.22 |
| CHEMBL3356959 | — | — | 2 | 7.96 |
| CHEMBL3356977 | — | — | 2 | 7.82 |
| CHEMBL3356975 | — | — | 2 | 7.64 |
| CHEMBL3356974 | — | — | 2 | 7.05 |
| CHEMBL3356962 | — | — | 2 | 6.85 |
| CHEMBL3356961 | — | — | 2 | 6.64 |
| CHEMBL1232635 | — | — | 2 | 6.55 |
| CHEMBL3356956 | — | — | 2 | 6.35 |
| CHEMBL3356979 | — | — | 2 | 6.15 |
| CHEMBL3356957 | — | — | 2 | 6.01 |
| CHEMBL3356985 | — | — | 2 | 5.79 |
| CHEMBL3356958 | — | — | 2 | 5.64 |
| CHEMBL2164594 | — | — | 2 | 5.52 |
| CHEMBL3087181 | — | — | 2 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356971 | — | IC50 | = | 2.692 | nM | 8.57 |
| CHEMBL3356971 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3356980 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3356960 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL3356960 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3356959 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3356959 | — | IC50 | = | 11.22 | nM | 7.95 |
| CHEMBL3356977 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3356977 | — | IC50 | = | 15.49 | nM | 7.81 |
| CHEMBL3356980 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL3356975 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3356975 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL3356974 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL3356974 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3356962 | — | IC50 | = | 141.25 | nM | 6.85 |
| CHEMBL3356962 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3356961 | — | IC50 | = | 229.09 | nM | 6.64 |
| CHEMBL3356961 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL1232635 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL1232635 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL3356956 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL3356956 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL3356979 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL3356979 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL3356957 | — | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL3356957 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL3356985 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL3356985 | — | IC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL3356958 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3356958 | — | IC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL2164594 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL2164594 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL3087181 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL3087181 | — | IC50 | = | 4800.0 | nM | 5.32 |