Compound Detail
CHEMBL3356979
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Basic Information
| ChEMBL ID | CHEMBL3356979 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FDUNIALFTNBMDG-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
413.5
MW (Da)
4.01
ALogP
6
HBA
0
HBD
63.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monoglyceride lipase CHEMBL4191 | IC50 | 7.16 | 7.16 | 69.2 | 2 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 6.15 | 6.15 | 708.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monoglyceride lipase | IC50 | = | 69.18 | nM | 7.16 | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as sub... | 25282655 |
| Monoglyceride lipase | IC50 | = | 70.0 | nM | 7.16 | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as sub... | 25282655 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 707.95 | nM | 6.15 | Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as... | 25282655 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 708.0 | nM | 6.15 | Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as... | 25282655 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25282655 | 10.1016/j.bmc.2014.09.012 | Monoglyceride lipase | 2 |
| 25282655 | 10.1016/j.bmc.2014.09.012 | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine