Assay Detail
Binding
CHEMBL3384571
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Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.78 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357106 | — | — | 1 | 7.05 |
| CHEMBL3357105 | — | — | 1 | 6.92 |
| CHEMBL3357108 | — | — | 1 | 6.52 |
| CHEMBL3357103 | — | — | 1 | 6.44 |
| CHEMBL3357111 | — | — | 1 | 6.33 |
| CHEMBL3357104 | — | — | 1 | 6.32 |
| CHEMBL3357099 | — | — | 1 | 6.02 |
| CHEMBL3357097 | — | — | 1 | 6.00 |
| CHEMBL3357116 | — | — | 1 | 6.00 |
| CHEMBL3357114 | — | — | 1 | 5.76 |
| CHEMBL3357124 | — | — | 1 | 5.52 |
| CHEMBL3357123 | — | — | 1 | 5.36 |
| CHEMBL3357118 | — | — | 1 | 5.36 |
| CHEMBL3357117 | — | — | 1 | 5.34 |
| CHEMBL3357121 | — | — | 1 | 5.30 |
| CHEMBL1470821 | — | — | 1 | 5.23 |
| CHEMBL3357095 | — | — | 1 | 5.22 |
| CHEMBL3357115 | — | — | 1 | 5.06 |
| CHEMBL3357113 | — | — | 1 | 5.01 |
| CHEMBL3357120 | — | — | 1 | 4.80 |
| CHEMBL3357083 | — | — | 1 | - |
| CHEMBL3357090 | — | — | 1 | - |
| CHEMBL3357089 | — | — | 1 | - |
| CHEMBL3357088 | — | — | 1 | - |
| CHEMBL3357087 | — | — | 1 | - |
| CHEMBL3357086 | — | — | 1 | - |
| CHEMBL3357085 | — | — | 1 | - |
| CHEMBL3357084 | — | — | 1 | - |
| CHEMBL3357093 | — | — | 1 | - |
| CHEMBL3357082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357106 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3357105 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3357108 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3357103 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3357111 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3357104 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3357099 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3357097 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3357116 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3357114 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3357124 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3357123 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3357118 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3357117 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3357121 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1470821 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3357095 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3357115 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3357113 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL3357120 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3357110 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357107 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357112 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL122 | ROFECOXIB | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357102 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357101 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357100 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357119 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357098 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357096 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357094 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357109 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357092 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357091 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357122 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357078 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357079 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357080 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357081 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357082 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357093 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357084 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357085 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357086 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357087 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357088 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357089 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357090 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3357083 | — | IC50 | > | 25000.0 | nM | - |