Assay Detail
Functional
CHEMBL3384577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 harboring reverse transcriptase Y181C mutant infected in human MT2 cells assessed as protection from virus-induced cytopathicity by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 6.91 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.19 |
| CHEMBL3342986 | — | — | 1 | 8.28 |
| CHEMBL3342991 | — | — | 1 | 8.25 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.10 |
| CHEMBL3342990 | — | — | 1 | 8.10 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.00 |
| CHEMBL3342988 | — | — | 1 | 8.00 |
| CHEMBL3342985 | — | — | 1 | 7.89 |
| CHEMBL1923492 | — | — | 1 | 7.80 |
| CHEMBL3342984 | — | — | 1 | 7.72 |
| CHEMBL3342992 | — | — | 1 | 7.50 |
| CHEMBL3342966 | — | — | 1 | 7.34 |
| CHEMBL3342989 | — | — | 1 | 7.32 |
| CHEMBL1923490 | — | — | 1 | 7.31 |
| CHEMBL3342987 | — | — | 1 | 7.31 |
| CHEMBL3342979 | — | — | 1 | 6.80 |
| CHEMBL3342976 | — | — | 1 | 6.77 |
| CHEMBL3342975 | — | — | 1 | 6.66 |
| CHEMBL3342978 | — | — | 1 | 6.60 |
| CHEMBL3342974 | — | — | 1 | 6.51 |
| CHEMBL3342983 | — | — | 1 | 6.37 |
| CHEMBL3342977 | — | — | 1 | 6.22 |
| CHEMBL3342982 | — | — | 1 | 6.00 |
| CHEMBL3342971 | — | — | 1 | 5.72 |
| CHEMBL3342972 | — | — | 1 | 5.46 |
| CHEMBL3342980 | — | — | 1 | 5.24 |
| CHEMBL3342981 | — | — | 1 | 4.92 |
| CHEMBL3342969 | — | — | 1 | 4.57 |
| CHEMBL3342967 | — | — | 1 | 4.42 |
| CHEMBL3342970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3342986 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3342991 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3342990 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3342988 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3342985 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1923492 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3342984 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3342992 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3342966 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3342989 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1923490 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3342987 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3342979 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3342976 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3342975 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3342978 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3342974 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3342983 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3342977 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3342982 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3342971 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3342972 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3342980 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3342981 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3342969 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3342967 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3342970 | — | EC50 | - | — | - | |
| CHEMBL3342968 | — | EC50 | - | — | - | |
| CHEMBL57 | NEVIRAPINE | EC50 | - | — | - | |
| CHEMBL3342973 | — | EC50 | - | — | - |