Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3384931

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human THP1 cells after 48 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type THP-1
Confidence 1 — Organism
Curated By Autocuration

Target

THP-1 (CHEMBL614245)
Type CELL-LINE
Organism Homo sapiens

Publication

β-Ionone derived apoptosis inducing endoperoxides; Discovery of potent leads for anticancer agents.
Sharma V, Chaudhry A, Chashoo G, Arora R, Arora S, Saxena AK, Ishar MP.
Eur J Med Chem (2014) 87 : 228 -236
PubMed 25259515 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.87 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185 FLUOROURACIL 4.0 1 7.40
CHEMBL3342653 1 7.00
CHEMBL105 MITOMYCIN 4.0 1 7.00
CHEMBL3342651 1 6.70
CHEMBL3342657 1 6.40
CHEMBL3342658 1 5.55
CHEMBL3342541 1 5.46
CHEMBL3342654 1 5.40
CHEMBL3342656 1 5.13
CHEMBL3342655 1 4.96
CHEMBL3342652 1 4.89
CHEMBL3341767 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185 FLUOROURACIL IC50 = 40.0 nM 7.40
CHEMBL3342653 IC50 = 100.0 nM 7.00
CHEMBL105 MITOMYCIN IC50 = 100.0 nM 7.00
CHEMBL3342651 IC50 = 200.0 nM 6.70
CHEMBL3342657 IC50 = 400.0 nM 6.40
CHEMBL3342658 IC50 = 2800.0 nM 5.55
CHEMBL3342541 IC50 = 3500.0 nM 5.46
CHEMBL3342654 IC50 = 4000.0 nM 5.40
CHEMBL3342656 IC50 = 7400.0 nM 5.13
CHEMBL3342655 IC50 = 11000.0 nM 4.96
CHEMBL3342652 IC50 = 13000.0 nM 4.89
CHEMBL3341767 IC50 = 25000.0 nM 4.60