Assay Detail
Binding
CHEMBL3385909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.56 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343301 | — | — | 1 | 7.00 |
| CHEMBL3343300 | — | — | 1 | 6.80 |
| CHEMBL3343299 | — | — | 1 | 4.96 |
| CHEMBL3343303 | — | — | 1 | 4.53 |
| CHEMBL3343302 | — | — | 1 | 4.51 |
| CHEMBL3343304 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343301 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3343300 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3343299 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL3343303 | — | Ki | = | 29800.0 | nM | 4.53 |
| CHEMBL3343302 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL3343304 | — | Ki | = | 133000.0 | nM | - |