Assay Detail
ADMET
CHEMBL3385974
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Inhibition of human recombinant CYP3A4 incubated for 5 mins by fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.93 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3331508 | — | — | 1 | 6.92 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 6.36 |
| CHEMBL3331484 | — | — | 1 | 6.30 |
| CHEMBL3331507 | — | — | 1 | 6.30 |
| CHEMBL3331504 | — | — | 1 | 6.09 |
| CHEMBL3331503 | — | — | 1 | 5.96 |
| CHEMBL3331469 | — | — | 1 | 5.88 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.60 |
| CHEMBL3331506 | — | — | 1 | 5.44 |
| CHEMBL3331502 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3331508 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1175 | DULOXETINE | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3331484 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3331507 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3331504 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3331503 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3331469 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3331506 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL3331502 | — | IC50 | = | 32700.0 | nM | 4.49 |