Assay Detail
Binding
CHEMBL3386398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL2304402) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.02 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354285 | — | — | 1 | 9.05 |
| CHEMBL3354279 | — | — | 1 | 8.92 |
| CHEMBL3354284 | — | — | 1 | 8.74 |
| CHEMBL3354264 | — | — | 1 | 8.68 |
| CHEMBL3354266 | — | — | 1 | 8.57 |
| CHEMBL3354273 | — | — | 1 | 8.46 |
| CHEMBL3354265 | — | — | 1 | 8.38 |
| CHEMBL1963681 | AVANAFIL | 4.0 | 1 | 8.28 |
| CHEMBL3354287 | — | — | 1 | 8.26 |
| CHEMBL3354270 | — | — | 1 | 8.25 |
| CHEMBL3354286 | — | — | 1 | 8.21 |
| CHEMBL3354278 | — | — | 1 | 8.19 |
| CHEMBL3352836 | — | — | 1 | 8.18 |
| CHEMBL3354272 | — | — | 1 | 7.92 |
| CHEMBL3354267 | — | — | 1 | 7.92 |
| CHEMBL3354271 | — | — | 1 | 7.89 |
| CHEMBL3354269 | — | — | 1 | 7.82 |
| CHEMBL3354282 | — | — | 1 | 7.60 |
| CHEMBL3354274 | — | — | 1 | 7.50 |
| CHEMBL3354275 | — | — | 1 | 7.50 |
| CHEMBL3354283 | — | — | 1 | 7.44 |
| CHEMBL3354277 | — | — | 1 | 7.27 |
| CHEMBL3354276 | — | — | 1 | 7.23 |
| CHEMBL3354281 | — | — | 1 | 7.20 |
| CHEMBL3354268 | — | — | 1 | 7.07 |
| CHEMBL3354280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354285 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3354279 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3354284 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3354264 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3354266 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3354273 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3354265 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1963681 | AVANAFIL | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3354287 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3354270 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3354286 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3354278 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3352836 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3354272 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3354267 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3354271 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3354269 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3354282 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3354274 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3354275 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3354283 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3354277 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3354276 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3354281 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3354268 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3354280 | — | IC50 | > | 100.0 | nM | - |