Compound Detail
CHEMBL3354281
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Basic Information
| ChEMBL ID | CHEMBL3354281 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AORKEOWCQWGPOB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
498.0
MW (Da)
2.68
ALogP
9
HBA
3
HBD
125.4
PSA (Ų)
0.41
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL2304402 | IC50 | 7.2 | 7.2 | 63.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 63.0 | nM | 7.2 | Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scinti... | 25455484 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25455484 | 10.1016/j.bmcl.2014.10.008 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine