Assay Detail
Functional
CHEMBL3387029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against epimastigote stage of Trypanosoma cruzi infected in Vero cells assessed as parasite growth inhibition after 24 hrs by hemocytometery
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines as antiparasitic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 4.45 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.40 |
| CHEMBL3330216 | — | — | 1 | 4.97 |
| CHEMBL3330183 | — | — | 1 | 4.93 |
| CHEMBL3330209 | — | — | 1 | 4.84 |
| CHEMBL3330184 | — | — | 1 | 4.83 |
| CHEMBL3329230 | — | — | 1 | 4.64 |
| CHEMBL3330182 | — | — | 1 | 4.61 |
| CHEMBL3330181 | — | — | 1 | 4.59 |
| CHEMBL3330179 | — | — | 1 | 4.56 |
| CHEMBL3330199 | — | — | 1 | 4.53 |
| CHEMBL3330186 | — | — | 1 | 4.51 |
| CHEMBL3330188 | — | — | 1 | 4.46 |
| CHEMBL3330222 | — | — | 1 | 4.37 |
| CHEMBL3330190 | — | — | 1 | 4.36 |
| CHEMBL3330213 | — | — | 1 | 4.34 |
| CHEMBL3330191 | — | — | 1 | 4.33 |
| CHEMBL3330196 | — | — | 1 | 4.33 |
| CHEMBL3330210 | — | — | 1 | 4.32 |
| CHEMBL3330197 | — | — | 1 | 4.32 |
| CHEMBL3330195 | — | — | 1 | 4.28 |
| CHEMBL3330194 | — | — | 1 | 4.28 |
| CHEMBL3330219 | — | — | 1 | 4.21 |
| CHEMBL3330180 | — | — | 1 | 4.21 |
| CHEMBL3330215 | — | — | 1 | 4.18 |
| CHEMBL3330214 | — | — | 1 | 4.06 |
| CHEMBL3330201 | — | — | 1 | 4.05 |
| CHEMBL3330193 | — | — | 1 | 4.03 |
| CHEMBL3330208 | — | — | 1 | 4.02 |
| CHEMBL3330202 | — | — | 1 | - |
| CHEMBL3330220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3330216 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3330183 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3330209 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3330184 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL3329230 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3330182 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL3330181 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL3330179 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL3330199 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL3330186 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3330188 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL3330222 | — | IC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL3330190 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL3330213 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL3330191 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL3330196 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL3330210 | — | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL3330197 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL3330195 | — | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL3330194 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL3330219 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL3330180 | — | IC50 | = | 62200.0 | nM | 4.21 |
| CHEMBL3330215 | — | IC50 | = | 65700.0 | nM | 4.18 |
| CHEMBL3330214 | — | IC50 | = | 87800.0 | nM | 4.06 |
| CHEMBL3330201 | — | IC50 | = | 89200.0 | nM | 4.05 |
| CHEMBL3330193 | — | IC50 | = | 92900.0 | nM | 4.03 |
| CHEMBL3330208 | — | IC50 | = | 95100.0 | nM | 4.02 |
| CHEMBL3330178 | — | IC50 | = | 146900.0 | nM | - |
| CHEMBL3330185 | — | IC50 | = | 104100.0 | nM | - |
| CHEMBL3330187 | — | IC50 | = | 102300.0 | nM | - |
| CHEMBL3330189 | — | IC50 | = | 142700.0 | nM | - |
| CHEMBL3330192 | — | IC50 | = | 229400.0 | nM | - |
| CHEMBL3330198 | — | IC50 | = | 192500.0 | nM | - |
| CHEMBL3330200 | — | IC50 | = | 165800.0 | nM | - |
| CHEMBL3330177 | — | IC50 | = | 198500.0 | nM | - |
| CHEMBL3330203 | — | IC50 | = | 150800.0 | nM | - |
| CHEMBL3330204 | — | IC50 | = | 192500.0 | nM | - |
| CHEMBL3330205 | — | IC50 | = | 414400.0 | nM | - |
| CHEMBL3330206 | — | IC50 | = | 219200.0 | nM | - |
| CHEMBL3330207 | — | IC50 | = | 142700.0 | nM | - |
| CHEMBL3330211 | — | IC50 | = | 763800.0 | nM | - |
| CHEMBL3330212 | — | IC50 | = | 163500.0 | nM | - |
| CHEMBL3330224 | — | IC50 | = | 601900.0 | nM | - |
| CHEMBL3330223 | — | IC50 | = | 176700.0 | nM | - |
| CHEMBL3330221 | — | IC50 | = | 605800.0 | nM | - |
| CHEMBL3330217 | — | IC50 | = | 884100.0 | nM | - |
| CHEMBL3330218 | — | IC50 | = | 119800.0 | nM | - |
| CHEMBL3330220 | — | IC50 | = | 115200.0 | nM | - |
| CHEMBL3330202 | — | IC50 | > | 842600.0 | nM | - |