Assay Detail
Binding
CHEMBL3388385
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Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X1 (CHEMBL3341575) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.47 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343989 | — | — | 1 | 6.50 |
| CHEMBL3343994 | — | — | 1 | 6.20 |
| CHEMBL3343988 | — | — | 1 | 5.40 |
| CHEMBL3343990 | — | — | 1 | 5.20 |
| CHEMBL1672380 | — | — | 1 | 5.20 |
| CHEMBL3343993 | — | — | 1 | 4.30 |
| CHEMBL475965 | — | — | 1 | - |
| CHEMBL3343987 | — | — | 1 | - |
| CHEMBL3343991 | — | — | 1 | - |
| CHEMBL3343992 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343989 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3343994 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3343988 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3343990 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL1672380 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL3343993 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL475965 | — | EC50 | > | 1995.26 | nM | - |
| CHEMBL3343987 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3343991 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3343992 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3343992 | — | EC50 | > | 100000.0 | nM | - |