Assay Detail
Binding
CHEMBL3389998
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Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in enzyme-catalyzed supercoiling of relaxed circular pBR322 DNA by agarose gel electrophoresis
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 4.15 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342828 | — | — | 1 | 4.89 |
| CHEMBL3343201 | — | — | 1 | 4.77 |
| CHEMBL3344385 | — | — | 1 | 4.30 |
| CHEMBL3342826 | — | — | 1 | 4.14 |
| CHEMBL3343194 | — | — | 1 | 4.14 |
| CHEMBL3343207 | — | — | 1 | 4.10 |
| CHEMBL3343193 | — | — | 1 | 4.05 |
| CHEMBL3342833 | — | — | 1 | 4.05 |
| CHEMBL205154 | TERFENADONE | — | 1 | 4.03 |
| CHEMBL3343208 | — | — | 1 | 4.03 |
| CHEMBL3343195 | — | — | 1 | 4.03 |
| CHEMBL3343205 | — | — | 1 | 4.03 |
| CHEMBL3342831 | — | — | 1 | 4.03 |
| CHEMBL3342832 | — | — | 1 | 4.03 |
| CHEMBL3343196 | — | — | 1 | 4.03 |
| CHEMBL3342830 | — | — | 1 | 4.03 |
| CHEMBL3342824 | — | — | 1 | 4.00 |
| CHEMBL3342835 | — | — | 1 | 4.00 |
| CHEMBL3344285 | — | — | 1 | - |
| CHEMBL3344284 | — | — | 1 | - |
| CHEMBL3343216 | — | — | 1 | - |
| CHEMBL3343210 | — | — | 1 | - |
| CHEMBL3343209 | — | — | 1 | - |
| CHEMBL3343206 | — | — | 1 | - |
| CHEMBL3343204 | — | — | 1 | - |
| CHEMBL3343203 | — | — | 1 | - |
| CHEMBL3343202 | — | — | 1 | - |
| CHEMBL3343199 | — | — | 1 | - |
| CHEMBL303454 | R-TERFENADINE | — | 1 | - |
| CHEMBL3343200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342828 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3343201 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3344385 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3342826 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL3343194 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL3343207 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3343193 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3342833 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3343196 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3342832 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3342831 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3342830 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3343205 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3343195 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3343208 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL205154 | TERFENADONE | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL3342824 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3342835 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 190000.0 | nM | - |
| CHEMBL432527 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL3342836 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342834 | — | IC50 | = | 193000.0 | nM | - |
| CHEMBL914 | FEXOFENADINE | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342829 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342827 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3343198 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3342823 | — | IC50 | = | 440000.0 | nM | - |
| CHEMBL3342822 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342821 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342820 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL3342819 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342818 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342817 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342816 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL3342825 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 110000.0 | nM | - |
| CHEMBL3344285 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3344284 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3343216 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL3343210 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3343209 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL3343206 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3343204 | — | IC50 | = | 263000.0 | nM | - |
| CHEMBL3343203 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3343202 | — | IC50 | > | 333000.0 | nM | - |
| CHEMBL3343199 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL303454 | R-TERFENADINE | IC50 | = | 410000.0 | nM | - |
| CHEMBL3343200 | — | IC50 | = | 247000.0 | nM | - |