Assay Detail
Binding
CHEMBL3390300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.31 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357790 | — | — | 1 | 8.24 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.20 |
| CHEMBL3357791 | — | — | 1 | 7.85 |
| CHEMBL3357792 | — | — | 1 | 7.70 |
| CHEMBL3357786 | — | — | 1 | 7.66 |
| CHEMBL3357788 | — | — | 1 | 7.66 |
| CHEMBL3357784 | — | — | 1 | 7.57 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.05 |
| CHEMBL3357785 | — | — | 1 | 6.97 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 6.90 |
| CHEMBL3357783 | — | — | 1 | 6.88 |
| CHEMBL296601 | — | — | 1 | 6.82 |
| CHEMBL1289403 | — | — | 1 | 6.74 |
| CHEMBL3357789 | — | — | 1 | 6.74 |
| CHEMBL3357787 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357790 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL3357791 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3357792 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3357786 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3357788 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3357784 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3357785 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL3357783 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL296601 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1289403 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL3357789 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL3357787 | — | Ki | = | 216.0 | nM | 6.67 |