Assay Detail
Binding
CHEMBL3390304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Irreversible inhibition of human CYP2A6 in baculovirus-infected insect cell system using coumarin 7 as substrate incubated for 10 mins by fluorescence assay
10
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design of novel CYP2A6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.87 | 6.89 |
| Kinact | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358202 | — | — | 1 | 6.89 |
| CHEMBL3358204 | — | — | 1 | 5.82 |
| CHEMBL3358207 | — | — | 2 | 5.62 |
| CHEMBL3358215 | — | — | 2 | 5.62 |
| CHEMBL3358216 | — | — | 2 | 5.62 |
| CHEMBL223708 | — | — | 2 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358202 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3358204 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3358207 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3358215 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3358216 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL223708 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3358207 | — | Kinact | = | 0.08 | /min | - |
| CHEMBL3358215 | — | Kinact | = | 0.08 | /min | - |
| CHEMBL3358216 | — | Kinact | = | 0.08 | /min | - |
| CHEMBL223708 | — | Kinact | = | 0.08 | /min | - |