Assay Detail
Binding
CHEMBL3390450
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Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 6 mins by spectrophotometric method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.06 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343930 | — | — | 1 | 8.37 |
| CHEMBL3343932 | — | — | 1 | 8.21 |
| CHEMBL3343926 | — | — | 1 | 8.12 |
| CHEMBL3343931 | — | — | 1 | 7.97 |
| CHEMBL3343928 | — | — | 1 | 7.65 |
| CHEMBL3343927 | — | — | 1 | 7.40 |
| CHEMBL3343922 | — | — | 1 | 7.38 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.30 |
| CHEMBL3343885 | — | — | 1 | 7.03 |
| CHEMBL3343882 | — | — | 1 | 7.01 |
| CHEMBL3343923 | — | — | 1 | 6.89 |
| CHEMBL3343884 | — | — | 1 | 6.80 |
| CHEMBL3343924 | — | — | 1 | 6.69 |
| CHEMBL3343929 | — | — | 1 | 6.62 |
| CHEMBL3343920 | — | — | 1 | 6.61 |
| CHEMBL3343925 | — | — | 1 | 6.48 |
| CHEMBL3343921 | — | — | 1 | 6.44 |
| CHEMBL3343883 | — | — | 1 | 6.27 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.90 |
| CHEMBL453066 | BETA-CCM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343930 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3343932 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3343926 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3343931 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL3343928 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL3343927 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL3343922 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL95 | TACRINE | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL3343885 | — | IC50 | = | 93.6 | nM | 7.03 |
| CHEMBL3343882 | — | IC50 | = | 96.9 | nM | 7.01 |
| CHEMBL3343923 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3343884 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3343924 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3343929 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3343920 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL3343925 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL3343921 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL3343883 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL453066 | BETA-CCM | IC50 | > | 100000.0 | nM | - |