Assay Detail
Functional
CHEMBL3392940
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DNDI: Cytotoxicity in Vitro, 96 hour, in primary peritoneal mouse macrophages
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.67 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.11 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 4.97 |
| CHEMBL3392934 | — | — | 1 | 4.80 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 4.69 |
| CHEMBL57004 | SITAMAQUINE | 2.0 | 1 | 4.67 |
| CHEMBL487366 | — | — | 1 | 4.65 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 4.64 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.62 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.49 |
| CHEMBL251689 | — | — | 1 | 4.40 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 10650.0 | nM | 4.97 |
| CHEMBL3392934 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 20270.0 | nM | 4.69 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 21370.0 | nM | 4.67 |
| CHEMBL487366 | — | IC50 | = | 22390.0 | nM | 4.65 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 22820.0 | nM | 4.64 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 23890.0 | nM | 4.62 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 32480.0 | nM | 4.49 |
| CHEMBL251689 | — | IC50 | = | 39720.0 | nM | 4.40 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 51070.0 | nM | 4.29 |