Assay Detail
Binding
CHEMBL3395080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein tyrosine phosphatase type IVA 3 (CHEMBL4162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.78 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393171 | — | — | 1 | 6.62 |
| CHEMBL3393148 | — | — | 1 | 4.50 |
| CHEMBL3393146 | — | — | 1 | 4.32 |
| CHEMBL398538 | — | — | 1 | 4.28 |
| CHEMBL3393149 | — | — | 1 | 4.16 |
| CHEMBL3393147 | — | — | 1 | - |
| CHEMBL3393150 | — | — | 1 | - |
| CHEMBL3393151 | — | — | 1 | - |
| CHEMBL3393152 | — | — | 1 | - |
| CHEMBL3393153 | — | — | 1 | - |
| CHEMBL3393154 | — | — | 1 | - |
| CHEMBL3393155 | — | — | 1 | - |
| CHEMBL3393156 | — | — | 1 | - |
| CHEMBL3393157 | — | — | 1 | - |
| CHEMBL3393158 | — | — | 1 | - |
| CHEMBL3393160 | — | — | 1 | - |
| CHEMBL3393161 | — | — | 1 | - |
| CHEMBL3393162 | — | — | 1 | - |
| CHEMBL3393163 | — | — | 1 | - |
| CHEMBL3393164 | — | — | 1 | - |
| CHEMBL3393165 | — | — | 1 | - |
| CHEMBL3393166 | — | — | 1 | - |
| CHEMBL3393167 | — | — | 1 | - |
| CHEMBL3393168 | — | — | 1 | - |
| CHEMBL3393169 | — | — | 1 | - |
| CHEMBL3393170 | — | — | 1 | - |
| CHEMBL3393159 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393171 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3393148 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL3393146 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL398538 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL3393149 | — | IC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL3393147 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL3393150 | — | IC50 | = | 109200.0 | nM | - |
| CHEMBL3393151 | — | IC50 | = | 167100.0 | nM | - |
| CHEMBL3393152 | — | IC50 | - | — | - | |
| CHEMBL3393153 | — | IC50 | - | — | - | |
| CHEMBL3393154 | — | IC50 | - | — | - | |
| CHEMBL3393155 | — | IC50 | - | — | - | |
| CHEMBL3393156 | — | IC50 | - | — | - | |
| CHEMBL3393157 | — | IC50 | - | — | - | |
| CHEMBL3393158 | — | IC50 | - | — | - | |
| CHEMBL3393160 | — | IC50 | - | — | - | |
| CHEMBL3393161 | — | IC50 | - | — | - | |
| CHEMBL3393162 | — | IC50 | - | — | - | |
| CHEMBL3393163 | — | IC50 | - | — | - | |
| CHEMBL3393164 | — | IC50 | - | — | - | |
| CHEMBL3393165 | — | IC50 | - | — | - | |
| CHEMBL3393166 | — | IC50 | - | — | - | |
| CHEMBL3393167 | — | IC50 | - | — | - | |
| CHEMBL3393168 | — | IC50 | - | — | - | |
| CHEMBL3393169 | — | IC50 | - | — | - | |
| CHEMBL3393170 | — | IC50 | - | — | - | |
| CHEMBL3393159 | — | IC50 | - | — | - |