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Assay Detail

CHEMBL3395903

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p38 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Inhibitors of c-Jun N-terminal kinases: an update.
Koch P, Gehringer M, Laufer SA.
J Med Chem (2015) 58 : 72 -95
PubMed 25415535 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 6.48 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1233748 1 7.52
CHEMBL1233747 1 5.43
CHEMBL3393599 1 -
CHEMBL571626 1 -
CHEMBL585951 1 -
CHEMBL2144409 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1233748 IC50 = 30.0 nM 7.52
CHEMBL1233747 IC50 = 3700.0 nM 5.43
CHEMBL3393599 IC50 > 20000.0 nM -
CHEMBL571626 IC50 > 20000.0 nM -
CHEMBL585951 IC50 > 20000.0 nM -
CHEMBL2144409 IC50 > 20000.0 nM -