Assay Detail

CHEMBL3396733

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ADMET

Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assay

ChEMBL ↗

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Target

Cytochrome P450 3A4 (CHEMBL340) ↗

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Cytochrome P450 3A4 (CHEMBL340) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 3A4

CHEMBL340

Anchored from Assay target.

Protein identity Cytochrome P450 3A4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Tissue	Liver
Subcellular	Microsomes
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 3A4 (CHEMBL340) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

SAR156497, an exquisitely selective inhibitor of aurora kinases.

Carry JC, Clerc F, Minoux H, Schio L, Mauger J, Nair A, Parmantier E, Le Moigne R, Delorme C, Nicolas JP, Krick A, Abécassis PY, Crocq-Stuerga V, Pouzieux S, Delarbre L, Maignan S, Bertrand T, Bjergarde K, Ma N, Lachaud S, Guizani H, Lebel R, Doerflinger G, Monget S, Perron S, Gasse F, Angouillant-Boniface O, Filoche-Rommé B, Murer M, Gontier S, Prévost C, Monteiro ML, Combeau C.
J Med Chem (2015) 58 : 362 -375
PubMed 25369539 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kinact	2	-	-
Ki	2	5.81	6.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3393498	—	—	2	6.00
CHEMBL655	MIDAZOLAM	4.0	2	5.61

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3393498	—	Ki	=	990.0	nM	6.00
CHEMBL655	MIDAZOLAM	Ki	=	2470.0	nM	5.61
CHEMBL3393498	—	Kinact	=	0.076	/min	-
CHEMBL655	MIDAZOLAM	Kinact	=	0.028	/min	-