Assay Detail
Functional
CHEMBL3396927
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Antiproliferative activity against human A2780 cells after 72 hrs by SRB method
39
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.78 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2420626 | — | — | 1 | 8.70 |
| CHEMBL3394724 | — | — | 3 | 8.70 |
| CHEMBL3394730 | — | — | 1 | 8.52 |
| CHEMBL3394721 | — | — | 1 | 8.40 |
| CHEMBL3394729 | — | — | 1 | 8.40 |
| CHEMBL2420620 | — | — | 1 | 8.30 |
| CHEMBL3394728 | — | — | 1 | 8.30 |
| CHEMBL3394725 | — | — | 1 | 8.22 |
| CHEMBL3394736 | — | — | 3 | 8.22 |
| CHEMBL3394734 | — | — | 1 | 8.22 |
| CHEMBL3394722 | — | — | 1 | 8.15 |
| CHEMBL2420623 | — | — | 1 | 8.05 |
| CHEMBL3394741 | — | — | 1 | 8.00 |
| CHEMBL3394723 | — | — | 3 | 8.00 |
| CHEMBL3394738 | — | — | 1 | 7.96 |
| CHEMBL3394733 | — | — | 1 | 7.96 |
| CHEMBL3394720 | — | — | 1 | 7.85 |
| CHEMBL3394715 | — | — | 1 | 7.77 |
| CHEMBL3394740 | — | — | 1 | 7.70 |
| CHEMBL2419504 | — | — | 1 | 7.64 |
| CHEMBL3394719 | — | — | 1 | 7.60 |
| CHEMBL3394737 | — | — | 1 | 7.57 |
| CHEMBL3394735 | — | — | 1 | 7.44 |
| CHEMBL3394727 | — | — | 1 | 7.43 |
| CHEMBL3394714 | — | — | 1 | 7.43 |
| CHEMBL3394717 | — | — | 1 | 7.33 |
| CHEMBL3394718 | — | — | 1 | 7.28 |
| CHEMBL3394726 | — | — | 1 | 7.08 |
| CHEMBL3394716 | — | — | 1 | 7.06 |
| CHEMBL3394739 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394724 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420626 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3394730 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3394721 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3394724 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3394729 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2420620 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3394728 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3394736 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3394725 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3394734 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3394722 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2420623 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3394741 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3394723 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3394733 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3394738 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3394720 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3394715 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3394740 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3394723 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2419504 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3394719 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3394737 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3394736 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3394735 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3394714 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3394727 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3394717 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3394718 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3394726 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3394716 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3394739 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3394713 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3394732 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL3394731 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL3394723 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3394736 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3394724 | — | IC50 | > | 2000.0 | nM | - |