Assay Detail
ADMET
CHEMBL3396934
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Reversible inhibition of CYP3A4 in human liver microsomes using midazolam as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.24 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394730 | — | — | 1 | 5.24 |
| CHEMBL3394719 | — | — | 1 | - |
| CHEMBL3394721 | — | — | 1 | - |
| CHEMBL3394722 | — | — | 1 | - |
| CHEMBL3394724 | — | — | 1 | - |
| CHEMBL3394729 | — | — | 1 | - |
| CHEMBL3394734 | — | — | 1 | - |
| CHEMBL3394736 | — | — | 1 | - |
| CHEMBL3394738 | — | — | 1 | - |
| CHEMBL3394741 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394730 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3394719 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394721 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394722 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394729 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394734 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394736 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394741 | — | IC50 | > | 10000.0 | nM | - |