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Assay Detail

CHEMBL3398734

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytostatic activity against human CEM cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors.
Potter E, Jha M, Bhullar KS, Rupasinghe HP, Balzarini J, Jha A.
Bioorg Med Chem (2015) 23 : 411 -421
PubMed 25577711 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 5.20 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL154716 1 6.05
CHEMBL3397752 1 6.05
CHEMBL3338598 1 6.00
CHEMBL3397746 1 5.96
CHEMBL3397747 1 5.92
CHEMBL3397753 1 5.85
CHEMBL1629985 1 5.77
CHEMBL574646 1 5.72
CHEMBL3397748 1 5.68
CHEMBL3397751 1 5.60
CHEMBL852 MELPHALAN 4.0 1 5.58
CHEMBL3397737 1 5.43
CHEMBL3397738 1 5.24
CHEMBL3397755 1 5.21
CHEMBL3397739 1 5.14
CHEMBL3397750 1 5.07
CHEMBL3397749 1 5.01
CHEMBL3397743 1 4.89
CHEMBL140 CURCUMIN 3.0 1 4.82
CHEMBL3397758 1 4.72
CHEMBL3397759 1 4.62
CHEMBL3397760 1 4.58
CHEMBL3397745 1 4.54
CHEMBL3397757 1 4.33
CHEMBL3397762 1 4.28
CHEMBL3397754 1 4.20
CHEMBL3397742 1 4.16
CHEMBL3397744 1 -
CHEMBL3397741 1 -
CHEMBL3397756 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL154716 IC50 = 900.0 nM 6.05
CHEMBL3397752 IC50 = 900.0 nM 6.05
CHEMBL3338598 IC50 = 1000.0 nM 6.00
CHEMBL3397746 IC50 = 1100.0 nM 5.96
CHEMBL3397747 IC50 = 1200.0 nM 5.92
CHEMBL3397753 IC50 = 1400.0 nM 5.85
CHEMBL1629985 IC50 = 1700.0 nM 5.77
CHEMBL574646 IC50 = 1900.0 nM 5.72
CHEMBL3397748 IC50 = 2100.0 nM 5.68
CHEMBL3397751 IC50 = 2500.0 nM 5.60
CHEMBL852 MELPHALAN IC50 = 2600.0 nM 5.58
CHEMBL3397737 IC50 = 3700.0 nM 5.43
CHEMBL3397738 IC50 = 5700.0 nM 5.24
CHEMBL3397755 IC50 = 6200.0 nM 5.21
CHEMBL3397739 IC50 = 7200.0 nM 5.14
CHEMBL3397750 IC50 = 8500.0 nM 5.07
CHEMBL3397749 IC50 = 9700.0 nM 5.01
CHEMBL3397743 IC50 = 13000.0 nM 4.89
CHEMBL140 CURCUMIN IC50 = 15000.0 nM 4.82
CHEMBL3397758 IC50 = 19000.0 nM 4.72
CHEMBL3397759 IC50 = 24000.0 nM 4.62
CHEMBL3397760 IC50 = 26000.0 nM 4.58
CHEMBL3397745 IC50 = 29000.0 nM 4.54
CHEMBL3397757 IC50 = 47000.0 nM 4.33
CHEMBL3397762 IC50 = 53000.0 nM 4.28
CHEMBL3397754 IC50 = 63000.0 nM 4.20
CHEMBL3397742 IC50 = 70000.0 nM 4.16
CHEMBL3397744 IC50 > 125000.0 nM -
CHEMBL3397741 IC50 > 250000.0 nM -
CHEMBL3397756 IC50 > 500000.0 nM -
CHEMBL3397761 IC50 > 250000.0 nM -
CHEMBL3397740 IC50 = 140000.0 nM -