Assay Detail
Functional
CHEMBL3404253
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Cytotoxicity against human HeLa 229 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa 229 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFRs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 6.85 |
| CHEMBL57366 | — | — | 1 | 5.41 |
| CHEMBL3401358 | — | — | 1 | 5.36 |
| CHEMBL3401370 | — | — | 1 | 5.01 |
| CHEMBL3401367 | — | — | 1 | 4.98 |
| CHEMBL3401369 | — | — | 1 | 4.96 |
| CHEMBL3401364 | — | — | 1 | 4.90 |
| CHEMBL3401363 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL57366 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL3401358 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL3401370 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL3401367 | — | IC50 | = | 10540.0 | nM | 4.98 |
| CHEMBL3401369 | — | IC50 | = | 10830.0 | nM | 4.96 |
| CHEMBL3401364 | — | IC50 | = | 12510.0 | nM | 4.90 |
| CHEMBL3401363 | — | IC50 | = | 15380.0 | nM | 4.81 |