Compound Detail
CHEMBL3401369
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3401369 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RERZHELNSZBVCM-UHFFFAOYSA-N |
6
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
308.3
MW (Da)
2.17
ALogP
5
HBA
4
HBD
119.6
PSA (Ų)
0.45
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.5 | 5.5 | 3170.0 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 5.12 | 5.12 | 7620.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.05 | 5.005 | 8960.0 | 2 |
| A549 CHEMBL392 | IC50 | 5.03 | 5.03 | 9390.0 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 4.71 | 4.71 | 19640.0 | 1 |
| ADMET CHEMBL612558 | IC50 | 4.32 | 4.32 | 47720.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 3170.0 | nM | 5.5 | Inhibition of FGFR1 (unknown origin) after 90 mins by TR-FRET assay | 25736993 |
| Fibroblast growth factor receptor 2 | IC50 | = | 7620.0 | nM | 5.12 | Inhibition of FGFR2 (unknown origin) after 90 mins by TR-FRET assay | 25736993 |
| NON-PROTEIN TARGET | IC50 | = | 8960.0 | nM | 5.05 | Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay | 25736993 |
| A549 | IC50 | = | 9390.0 | nM | 5.03 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 25736993 |
| NON-PROTEIN TARGET | IC50 | = | 10830.0 | nM | 4.96 | Cytotoxicity against human HeLa 229 cells after 72 hrs by MTT assay | 25736993 |
| Fibroblast growth factor receptor 3 | IC50 | = | 19640.0 | nM | 4.71 | Inhibition of FGFR3 (unknown origin) after 90 mins by TR-FRET assay | 25736993 |
| ADMET | IC50 | = | 47720.0 | nM | 4.32 | Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay | 25736993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25736993 | 10.1016/j.bmcl.2015.02.010 | NON-PROTEIN TARGET | 2 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 4 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 3 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 2 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 1 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | A549 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine