Assay Detail
ADMET
CHEMBL3404450
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Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFRs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.43 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 4.74 |
| CHEMBL3401358 | — | — | 1 | 4.56 |
| CHEMBL57366 | — | — | 1 | 4.55 |
| CHEMBL3401363 | — | — | 1 | 4.33 |
| CHEMBL3401370 | — | — | 1 | 4.33 |
| CHEMBL3401364 | — | — | 1 | 4.32 |
| CHEMBL3401369 | — | — | 1 | 4.32 |
| CHEMBL3401367 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 18210.0 | nM | 4.74 |
| CHEMBL3401358 | — | IC50 | = | 27590.0 | nM | 4.56 |
| CHEMBL57366 | — | IC50 | = | 28370.0 | nM | 4.55 |
| CHEMBL3401363 | — | IC50 | = | 46970.0 | nM | 4.33 |
| CHEMBL3401370 | — | IC50 | = | 46640.0 | nM | 4.33 |
| CHEMBL3401364 | — | IC50 | = | 47840.0 | nM | 4.32 |
| CHEMBL3401369 | — | IC50 | = | 47720.0 | nM | 4.32 |
| CHEMBL3401367 | — | IC50 | = | 49980.0 | nM | 4.30 |