Assay Detail
Binding
CHEMBL3405466
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Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman spectrophotometric method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.38 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292314 | — | — | 1 | 7.78 |
| CHEMBL3403877 | — | — | 1 | 6.54 |
| CHEMBL3400187 | — | — | 1 | 6.49 |
| CHEMBL3403874 | — | — | 1 | 6.33 |
| CHEMBL3403872 | — | — | 1 | 6.26 |
| CHEMBL3403875 | — | — | 1 | 6.09 |
| CHEMBL3403878 | — | — | 1 | 6.01 |
| CHEMBL3403876 | — | — | 1 | 5.99 |
| CHEMBL3403873 | — | — | 1 | 5.91 |
| CHEMBL74490 | — | — | 1 | - |
| CHEMBL3401031 | — | — | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292314 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL3403877 | — | IC50 | = | 291.3 | nM | 6.54 |
| CHEMBL3400187 | — | IC50 | = | 320.9 | nM | 6.49 |
| CHEMBL3403874 | — | IC50 | = | 463.2 | nM | 6.33 |
| CHEMBL3403872 | — | IC50 | = | 549.4 | nM | 6.26 |
| CHEMBL3403875 | — | IC50 | = | 818.9 | nM | 6.09 |
| CHEMBL3403878 | — | IC50 | = | 968.9 | nM | 6.01 |
| CHEMBL3403876 | — | IC50 | = | 1021.0 | nM | 5.99 |
| CHEMBL3403873 | — | IC50 | = | 1242.4 | nM | 5.91 |
| CHEMBL74490 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3401031 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | - | — | - |