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Assay Detail

CHEMBL3405795

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trichomonicidal activity against Trichomonas vaginalis GT3 compound treated for 48 hrs followed by incubation for 48 hrs in compound-free medium by cell counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trichomonas vaginalis
Confidence 1 — Organism
Curated By Autocuration

Target

Trichomonas vaginalis (CHEMBL612884)
Type ORGANISM
Organism Trichomonas vaginalis

Publication

Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis.
Navarrete-Vázquez G, Chávez-Silva F, Colín-Lozano B, Estrada-Soto S, Hidalgo-Figueroa S, Guerrero-Álvarez J, Méndez ST, Reyes-Vivas H, Oria-Hernández J, Canul-Canché J, Ortiz-Andrade R, Moo-Puc R.
Bioorg Med Chem (2015) 23 : 2204 -2210
PubMed 25801157 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.12 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1872946 NITHIAMIDE 2.0 1 7.66
CHEMBL1401 NITAZOXANIDE 4.0 1 7.17
CHEMBL1545 TIZOXANIDE -1.0 1 6.68
CHEMBL3401735 1 6.66
CHEMBL137 METRONIDAZOLE 4.0 1 6.54
CHEMBL3401733 1 6.52
CHEMBL1577852 1 6.48
CHEMBL318275 1 6.20
CHEMBL3401732 1 5.69
CHEMBL3401730 1 5.65
CHEMBL3401734 1 5.49
CHEMBL3401736 1 5.46
CHEMBL3401731 1 5.21
CHEMBL408049 1 4.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1872946 NITHIAMIDE IC50 = 22.0 nM 7.66
CHEMBL1401 NITAZOXANIDE IC50 = 68.0 nM 7.17
CHEMBL1545 TIZOXANIDE IC50 = 211.0 nM 6.68
CHEMBL3401735 IC50 = 221.0 nM 6.66
CHEMBL137 METRONIDAZOLE IC50 = 290.0 nM 6.54
CHEMBL3401733 IC50 = 305.0 nM 6.52
CHEMBL1577852 IC50 = 331.0 nM 6.48
CHEMBL318275 IC50 = 625.0 nM 6.20
CHEMBL3401732 IC50 = 2036.0 nM 5.69
CHEMBL3401730 IC50 = 2247.0 nM 5.65
CHEMBL3401734 IC50 = 3212.0 nM 5.49
CHEMBL3401736 IC50 = 3431.0 nM 5.46
CHEMBL3401731 IC50 = 6099.0 nM 5.21
CHEMBL408049 IC50 = 52850.0 nM 4.28