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Compound Detail

CHEMBL408049

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Nc1ncc([N+](=O)[O-])s1

Basic Information

ChEMBL ID CHEMBL408049
Phase Preclinical
Structure Type MOL
InChI Key MIHADVKEHAFNPG-UHFFFAOYSA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names

Molecular Properties

145.1
MW (Da)
0.63
ALogP
5
HBA
1
HBD
82.0
PSA (Ų)
0.46
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C3H3N3O2S
MW 145.14
Aromatic Rings 1
Heavy Atoms 9
NP-Likeness -2.07

Activity Summary

IC50 6 meas. best 4.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 4.56 4.54 27542.3 3
Trichomonas vaginalis
CHEMBL612884
IC50 4.28 4.2533 52850.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18295489 10.1016/j.bmc.2007.11.029 Rattus norvegicus 2
23750537 10.1021/jm4001488 5'-AMP-activated protein kinase catalytic subunit alpha-2 2
24529307 10.1016/j.bmc.2014.01.029 Trichomonas vaginalis 2
24529307 10.1016/j.bmc.2014.01.029 Giardia intestinalis 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
23750537 10.1021/jm4001488 Unchecked 1
24529307 10.1016/j.bmc.2014.01.029 Vero 1
24529307 10.1016/j.bmc.2014.01.029 Trypanosoma cruzi 1
24529307 10.1016/j.bmc.2014.01.029 Leishmania amazonensis 1
25801157 10.1016/j.bmc.2015.02.059 Giardia intestinalis 1
25801157 10.1016/j.bmc.2015.02.059 Trichomonas vaginalis 1
25801157 10.1016/j.bmc.2015.02.059 Unchecked 1
25801157 10.1016/j.bmc.2015.02.059 Vero 1

Data from ChEMBL 36 via Core Engine