Assay Detail
Binding
CHEMBL3407205
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Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.66 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290096 | — | — | 1 | 6.75 |
| CHEMBL3290101 | — | — | 1 | 5.92 |
| CHEMBL3290105 | — | — | 1 | 5.49 |
| CHEMBL3403505 | — | — | 1 | 5.14 |
| CHEMBL3403506 | — | — | 1 | 4.99 |
| CHEMBL461604 | — | — | 1 | - |
| CHEMBL3403504 | — | — | 1 | - |
| CHEMBL3403507 | — | — | 1 | - |
| CHEMBL3290106 | — | — | 1 | - |
| CHEMBL3403508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290096 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL3290101 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL3290105 | — | Ki | = | 3210.0 | nM | 5.49 |
| CHEMBL3403505 | — | Ki | = | 7181.0 | nM | 5.14 |
| CHEMBL3403506 | — | Ki | = | 10162.0 | nM | 4.99 |
| CHEMBL461604 | — | Ki | - | — | - | |
| CHEMBL3403504 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3403507 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL3290106 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL3403508 | — | Ki | > | 25000.0 | nM | - |