Assay Detail
Binding
CHEMBL3412811
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Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.29 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410952 | — | — | 1 | 7.81 |
| CHEMBL3410954 | — | — | 1 | 7.65 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.45 |
| CHEMBL3410953 | — | — | 1 | 7.45 |
| CHEMBL3410951 | — | — | 1 | 7.38 |
| CHEMBL3410955 | — | — | 1 | 7.21 |
| CHEMBL3410956 | — | — | 1 | 6.82 |
| CHEMBL3410957 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410952 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL3410954 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL95 | TACRINE | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL3410953 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL3410951 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL3410955 | — | IC50 | = | 61.7 | nM | 7.21 |
| CHEMBL3410956 | — | IC50 | = | 150.5 | nM | 6.82 |
| CHEMBL3410957 | — | IC50 | = | 262.8 | nM | 6.58 |