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Assay Detail

CHEMBL3413799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathogenicity after 4 days by cell-Titer Glo assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Respiratory syncytial virus
Cell Type HEp-2
Confidence 1 — Organism
Curated By Autocuration

Target

Respiratory syncytial virus (CHEMBL612679)
Type ORGANISM
Organism Respiratory syncytial virus

Publication

Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
Mackman RL, Sangi M, Sperandio D, Parrish JP, Eisenberg E, Perron M, Hui H, Zhang L, Siegel D, Yang H, Saunders O, Boojamra C, Lee G, Samuel D, Babaoglu K, Carey A, Gilbert BE, Piedra PA, Strickley R, Iwata Q, Hayes J, Stray K, Kinkade A, Theodore D, Jordan R, Desai M, Cihlar T.
J Med Chem (2015) 58 : 1630 -1643
PubMed 25574686 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 42 7.65 9.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3410450 PRESATOVIR 2.0 1 9.43
CHEMBL3410445 1 9.19
CHEMBL3410446 1 9.14
CHEMBL3410438 1 8.96
CHEMBL3410435 1 8.92
CHEMBL3410442 1 8.82
CHEMBL3410441 1 8.82
CHEMBL3410436 1 8.68
CHEMBL3410449 1 8.59
CHEMBL3410439 1 8.52
CHEMBL3410443 1 8.36
CHEMBL3410447 1 8.35
CHEMBL3410423 1 8.30
CHEMBL3410444 1 8.27
CHEMBL3410433 1 8.26
CHEMBL3410437 1 8.15
CHEMBL3410448 1 8.12
CHEMBL3410432 1 8.12
CHEMBL3410431 1 8.03
CHEMBL3407530 1 7.85
CHEMBL3410440 1 7.70
CHEMBL3410434 1 7.64
CHEMBL3410430 1 7.57
CHEMBL3410425 1 7.54
CHEMBL3410427 1 7.35
CHEMBL3410429 1 7.31
CHEMBL3410416 1 7.24
CHEMBL3410412 1 7.19
CHEMBL3410420 1 7.13
CHEMBL3410422 1 7.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3410450 PRESATOVIR EC50 = 0.37 nM 9.43
CHEMBL3410445 EC50 = 0.64 nM 9.19
CHEMBL3410446 EC50 = 0.72 nM 9.14
CHEMBL3410438 EC50 = 1.1 nM 8.96
CHEMBL3410435 EC50 = 1.2 nM 8.92
CHEMBL3410442 EC50 = 1.5 nM 8.82
CHEMBL3410441 EC50 = 1.5 nM 8.82
CHEMBL3410436 EC50 = 2.1 nM 8.68
CHEMBL3410449 EC50 = 2.6 nM 8.59
CHEMBL3410439 EC50 = 3.0 nM 8.52
CHEMBL3410443 EC50 = 4.4 nM 8.36
CHEMBL3410447 EC50 = 4.5 nM 8.35
CHEMBL3410423 EC50 = 5.0 nM 8.30
CHEMBL3410444 EC50 = 5.4 nM 8.27
CHEMBL3410433 EC50 = 5.5 nM 8.26
CHEMBL3410437 EC50 = 7.0 nM 8.15
CHEMBL3410448 EC50 = 7.5 nM 8.12
CHEMBL3410432 EC50 = 7.5 nM 8.12
CHEMBL3410431 EC50 = 9.4 nM 8.03
CHEMBL3407530 EC50 = 14.0 nM 7.85
CHEMBL3410440 EC50 = 20.0 nM 7.70
CHEMBL3410434 EC50 = 23.0 nM 7.64
CHEMBL3410430 EC50 = 27.0 nM 7.57
CHEMBL3410425 EC50 = 29.0 nM 7.54
CHEMBL3410427 EC50 = 45.0 nM 7.35
CHEMBL3410429 EC50 = 49.0 nM 7.31
CHEMBL3410416 EC50 = 57.0 nM 7.24
CHEMBL3410412 EC50 = 65.0 nM 7.19
CHEMBL3410420 EC50 = 74.0 nM 7.13
CHEMBL3410422 EC50 = 81.0 nM 7.09
CHEMBL3410428 EC50 = 180.0 nM 6.75
CHEMBL3410410 EC50 = 202.0 nM 6.70
CHEMBL3410417 EC50 = 212.0 nM 6.67
CHEMBL3410418 EC50 = 305.0 nM 6.52
CHEMBL3410415 EC50 = 331.0 nM 6.48
CHEMBL3410421 EC50 = 402.0 nM 6.40
CHEMBL3410419 EC50 = 429.0 nM 6.37
CHEMBL3410413 EC50 = 586.0 nM 6.23
CHEMBL3410414 EC50 = 861.0 nM 6.07
CHEMBL3410424 EC50 = 2606.0 nM 5.58
CHEMBL3410411 EC50 = 4700.0 nM 5.33
CHEMBL3410426 EC50 > 10000.0 nM -