Assay Detail
Binding
CHEMBL3418289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414922 | — | — | 1 | 9.00 |
| CHEMBL3414926 | — | — | 1 | 9.00 |
| CHEMBL3414925 | — | — | 1 | 8.70 |
| CHEMBL3414923 | — | — | 1 | 8.70 |
| CHEMBL3414918 | — | — | 1 | 8.70 |
| CHEMBL3414914 | — | — | 1 | 8.70 |
| CHEMBL3414913 | — | — | 1 | 8.52 |
| CHEMBL3414738 | — | — | 1 | 8.40 |
| CHEMBL3414919 | — | — | 1 | 8.30 |
| CHEMBL3414917 | — | — | 1 | 8.30 |
| CHEMBL3414577 | — | — | 1 | 8.30 |
| CHEMBL3414731 | — | — | 1 | 8.15 |
| CHEMBL3414920 | — | — | 1 | 8.15 |
| CHEMBL3414921 | — | — | 1 | 8.05 |
| CHEMBL3414736 | — | — | 1 | 8.05 |
| CHEMBL496102 | AMG-208 | 2.0 | 1 | 8.05 |
| CHEMBL3414742 | — | — | 1 | 7.96 |
| CHEMBL3414737 | — | — | 1 | 7.96 |
| CHEMBL3414915 | — | — | 1 | 7.92 |
| CHEMBL3414735 | — | — | 1 | 7.92 |
| CHEMBL3414741 | — | — | 1 | 7.75 |
| CHEMBL3414739 | — | — | 1 | 7.66 |
| CHEMBL3414734 | — | — | 1 | 7.64 |
| CHEMBL3414740 | — | — | 1 | 7.62 |
| CHEMBL3414929 | — | — | 1 | 7.55 |
| CHEMBL3414730 | — | — | 1 | 7.51 |
| CHEMBL3414743 | — | — | 1 | 7.29 |
| CHEMBL3414912 | — | — | 1 | 7.28 |
| CHEMBL3414733 | — | — | 1 | 7.22 |
| CHEMBL3414745 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414922 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3414926 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3414923 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3414918 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3414914 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3414925 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3414913 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3414738 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3414577 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3414917 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3414919 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3414731 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3414920 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL496102 | AMG-208 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3414736 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3414921 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3414742 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3414737 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3414915 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3414735 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3414741 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3414739 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3414734 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3414740 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3414929 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3414730 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3414743 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3414912 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3414733 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3414745 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3414928 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3414744 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3414732 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3414924 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3414916 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL496101 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3414927 | — | IC50 | > | 400.0 | nM | - |