Assay Detail
Binding
CHEMBL3420218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE pre-incubated for 5 mins before butyrylthiocholine iodide substrate by Ellman' method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.29 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417001 | — | — | 1 | 5.74 |
| CHEMBL3417009 | — | — | 1 | 5.45 |
| CHEMBL3417006 | — | — | 1 | 5.44 |
| CHEMBL3416997 | — | — | 1 | 5.40 |
| CHEMBL3417008 | — | — | 1 | 5.39 |
| CHEMBL3417000 | — | — | 1 | 5.36 |
| CHEMBL3416999 | — | — | 1 | 5.20 |
| CHEMBL3414597 | — | — | 1 | 5.18 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.16 |
| CHEMBL3416996 | — | — | 1 | 5.16 |
| CHEMBL3417004 | — | — | 1 | 5.15 |
| CHEMBL3417005 | — | — | 1 | 5.13 |
| CHEMBL3417002 | — | — | 1 | 5.04 |
| CHEMBL3417007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417001 | — | IC50 | = | 1835.0 | nM | 5.74 |
| CHEMBL3417009 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL3417006 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL3416997 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3417008 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3417000 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL3416999 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL3414597 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3416996 | — | IC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL3417004 | — | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL3417005 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL3417002 | — | IC50 | = | 9165.0 | nM | 5.04 |
| CHEMBL3417007 | — | IC50 | - | — | - |