Assay Detail
Binding
CHEMBL3420280
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Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.23 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417485 | — | — | 1 | 8.77 |
| CHEMBL3417484 | — | — | 1 | 8.64 |
| CHEMBL3417489 | — | — | 1 | 8.38 |
| CHEMBL3414602 | — | — | 1 | 8.34 |
| CHEMBL3417487 | — | — | 1 | 8.28 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.15 |
| CHEMBL3417482 | — | — | 1 | 8.05 |
| CHEMBL3417486 | — | — | 1 | 8.01 |
| CHEMBL3417483 | — | — | 1 | 8.00 |
| CHEMBL3417488 | — | — | 1 | 7.97 |
| CHEMBL3417475 | — | — | 1 | 7.77 |
| CHEMBL3417479 | — | — | 1 | 7.72 |
| CHEMBL3417480 | — | — | 1 | 7.70 |
| CHEMBL3417478 | — | — | 1 | 7.62 |
| CHEMBL3417481 | — | — | 1 | 7.44 |
| CHEMBL3417474 | — | — | 1 | 7.40 |
| CHEMBL3417472 | — | — | 1 | 7.34 |
| CHEMBL3417476 | — | — | 1 | 7.29 |
| CHEMBL3417493 | — | — | 1 | 7.07 |
| CHEMBL3417498 | — | — | 1 | 7.05 |
| CHEMBL3417467 | — | — | 1 | 7.00 |
| CHEMBL3417495 | — | — | 1 | 6.82 |
| CHEMBL3417464 | — | — | 1 | 6.80 |
| CHEMBL3417473 | — | — | 1 | 6.72 |
| CHEMBL3417496 | — | — | 1 | 6.72 |
| CHEMBL3417470 | — | — | 1 | 6.70 |
| CHEMBL3417461 | — | — | 1 | 6.68 |
| CHEMBL3417469 | — | — | 1 | 6.52 |
| CHEMBL3417497 | — | — | 1 | 6.50 |
| CHEMBL3417459 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417485 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3417484 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3417489 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3414602 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3417487 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3417482 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3417486 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3417483 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3417488 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL3417475 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3417479 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3417480 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3417478 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3417481 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3417474 | — | IC50 | = | 39.5 | nM | 7.40 |
| CHEMBL3417472 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3417476 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3417493 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3417498 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3417467 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3417495 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL3417464 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3417473 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3417496 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3417470 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3417461 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3417469 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3417497 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3417459 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3417471 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3417494 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL3417468 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3417460 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3417465 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3417466 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3417491 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3417492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3417477 | — | IC50 | > | 10000.0 | nM | - |