Compound Detail
CHEMBL3417483
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CN1CCN(CCCCCOC(=O)Nc2cccc(Cn3nc(-n4ccc5ccc(F)cc54)ccc3=O)c2)CC1
Basic Information
| ChEMBL ID | CHEMBL3417483 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RQBZZEDXQSBJPJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
546.6
MW (Da)
4.34
ALogP
8
HBA
1
HBD
84.6
PSA (Ų)
0.30
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 10.0 | nM | 8.0 | Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substra... | 25827399 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25827399 | 10.1016/j.ejmech.2015.03.041 | Hepatocyte growth factor receptor | 1 |
| 25827399 | 10.1016/j.ejmech.2015.03.041 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine