Assay Detail
Binding
CHEMBL3420499
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Inhibition of Human MetAP1b using Met-pNA as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.86 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414950 | — | — | 1 | 5.31 |
| CHEMBL1673064 | — | — | 1 | 5.00 |
| CHEMBL1673077 | — | — | 1 | 4.26 |
| CHEMBL1673062 | — | — | 1 | - |
| CHEMBL3414949 | — | — | 1 | - |
| CHEMBL1090366 | AMINO(PHENYL)METHYLPHOSPHONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414950 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL1673064 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL1673077 | — | Ki | = | 54800.0 | nM | 4.26 |
| CHEMBL1673062 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3414949 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1090366 | AMINO(PHENYL)METHYLPHOSPHONIC ACID | Ki | = | 111600.0 | nM | - |