Assay Detail
ADMET
CHEMBL3425002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.48 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422009 | — | — | 1 | 5.16 |
| CHEMBL3421983 | — | — | 1 | 4.82 |
| CHEMBL3422014 | — | — | 1 | 4.57 |
| CHEMBL3422018 | — | — | 1 | 4.41 |
| CHEMBL3422016 | — | — | 1 | 4.38 |
| CHEMBL3422006 | — | — | 1 | 4.27 |
| CHEMBL3422015 | — | — | 1 | 4.19 |
| CHEMBL3422007 | — | — | 1 | 4.07 |
| CHEMBL3422017 | — | — | 1 | - |
| CHEMBL3422013 | — | — | 1 | - |
| CHEMBL3422012 | — | — | 1 | - |
| CHEMBL3422010 | — | — | 1 | - |
| CHEMBL3421982 | — | — | 1 | - |
| CHEMBL3422008 | — | — | 1 | - |
| CHEMBL3422005 | — | — | 1 | - |
| CHEMBL3422004 | — | — | 1 | - |
| CHEMBL3422000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422009 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3421983 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3422014 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3422018 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3422016 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3422006 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL3422015 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3422007 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL3422017 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3422013 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3422012 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3422010 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3421982 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL3422008 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3422005 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3422004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3422000 | — | IC50 | > | 100000.0 | nM | - |